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KMID : 0043320070300091062
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Archives of Pharmacal Research
2007 Volume.30 No. 9 p.1062 ~ p.1066
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A Phenylpropanoid Glycoside with Antioxidant Activity from Picria tel-ferae
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Thuan Nguyen Duy
Ha Do Thi
Thuong Thien
Na Min-Kyun
Lee Jong-Pill
Lee Jeong-Hun
Seo Hyo-Won
Min Byung-Sun
Bae Ki-Hwan
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Abstract
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A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as 1-O-3,4-(dihydroxyphenyl)-ethyl-β-D-apiofuranosyl-(1→4)-α-L-rharmnopyranosyl- (1→3)-4-O-caffeoyl-β-D-glucopyranoside on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2’-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical (Fe2+/ascorbate). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases
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KEYWORD
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Picria tel-ferae, Scrophulariaceae, Phenylpropanoid glycoside, Antioxidant, Lipid peroxidation
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